By T. Hugh Jones
Testosterone has a huge impression on significant organ structures and tissues, together with mind, metabolism, cardiovascular in addition to musculoskeletal and immune structures. masking many medical components, this booklet can pay specific recognition to the analysis and administration of hypogonadism, discussing present guidance, biochemical overview, new innovations in testosterone substitute treatment and long term tracking of handled males. in addition the function of testosterone deficiency in getting older, weight problems, muscle functionality and frailty and erectile disorder is covered.Recent proof for the function of testosterone within the pathogenesis of continual ailments comparable to diabetes, heart problems and osteoporosis is suggested. New advancements within the capability therapy of those medical stipulations also are. provided. essentially of curiosity to endocrinologists, urologists, andrologists and sexologists, the diversity of themes coated can be suitable to basic care physicians, gerontologists, diabetologists and cardiologists.
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Additional info for Advances in the Management of Testosterone Deficiency (Frontiers of Hormone Research Vol 37)
Transdermal scrotal testosterone administration is associated with high levels of DHT as a result of high concentrations of 5␣-reductase in the scrotal skin . The patch may be irritating and its use is not feasible if there is not sufficient scrotal surface. The scrotal patches sometimes fell off the scrotum leaving the patient undersubstituted. To overcome these limitations, nonscrotal skin patches have been developed. Nonscrotal Testosterone Patch These patches have a reservoir containing testosterone with a permeation-enhancing vehicle and gelling agents .
Part of it is probably reduced to DHT. Studies demonstrated that application of the testosterone gel at a single site versus four separate sites resulted in a similar delivery rate of testosterone, indicating that the site of application and its related properties of the skin do not represent a barrier to testosterone absorption . The formulation of the testosterone gel allows easy dose adjustments (50-, 75- and 100-mg testosterone gel) , though in most countries only the 50-mg gel is available commercially.
6) It is unlikely that salivary testosterone offers any benefit at present to the routine assessment of androgen status. Testosterone Assays 29 References 1 Taieb J, Mathian B, Millot F, Patricot M-C, Mathieu E, Queyrel N, Lacroix I, Somma-Delperro C, Boudou P: Testosterone measured by 10 immunoassays and by isotope-dilution gas chromatography-mass spectrometry in sera from 1116 men, women and children. Clin Chem 2003;49:1381–1395. 2 Rosner W, Auchus RJ, Azziz R, Sluss PM, Raff H: Utility, limitations and pitfalls in measuring testosterone: an Endocrine Society Position Statement.
Advances in the Management of Testosterone Deficiency (Frontiers of Hormone Research Vol 37) by T. Hugh Jones
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