February 10, 2018

Read e-book online A Comprehensive Guide to Toxicology in Preclinical Drug PDF

By Ali S. Faqi (Auth.)

ISBN-10: 0123878152

ISBN-13: 9780123878151

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Additional info for A Comprehensive Guide to Toxicology in Preclinical Drug Development

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Utility of the parent-neutral loss scan screening technique: partial characterization of urinary metabolites of U-78875 in monkey urine. Biological Mass Spectrometry 1992;21:517e22. [80] Zhu M, Zhang H, Humphreys WG. Drug metabolite profiling and identification by high-resolution mass spectrometry. J Biol Chem 2011;286:25419e25. [81] Perry RH, Cooks RG, Noll RJ. Orbitrap mass spectrometry: Instrumentation, ion motion and applications. Mass Spectrometry Reviews 2008;27:661e99. [82] Obach RS, Nedderman AN, Smith DA.

Quite commonly, elimination of small molecules occurs in several organs, such as the liver and the kidneys, although one may predominate. Because blood flow is fractionally distributed between the various potential organs of elimination, clearance from these organs is a parallel process. 6) One exception to this relationship occurs when there is significant elimination by the lung, for which blood flow is in series rather than in parallel with all of the other organs. Obviously, organ-specific pathology may impact organ-specific CL, which in turn will affect the total observed CL.

New York: McGraw-Hill Companies; 2007. [87] Leung L, Kalgutkar AS, Obach RS. Metabolic activation in druginduced liver injury. Drug Metab Rev 2012;44:18e33. [88] Pessayre D, Fromenty B, Berson A, Robin M-A, Lette´ron P, Moreau R, et al. Central role of mitochondria in drug-induced liver injury. Drug Metab Rev 2012;44:34e87. [89] Jaeschke H, McGill MR, Ramachandran A. Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity.

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A Comprehensive Guide to Toxicology in Preclinical Drug Development by Ali S. Faqi (Auth.)


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