February 11, 2018

New PDF release: 50 studies every neurologist should know

By David Y. Hwang

ISBN-10: 0199377529

ISBN-13: 9780199377527

50 experiences each Neurologist may still Know offers key experiences that form the present medical perform of neurology. All neurologic subspecialties are coated, with a unique emphasis on neurocritical care and vascular neurology. for every examine, a concise precis is gifted with an emphasis at the effects and barriers of the research, and its implications for perform. An illustrative scientific case concludes every one evaluate, by way of short info on different correct reviews. this can be the 1st booklet of its type to give a suite of the main influential scientific trials in neurology which are special sufficient for use on rounds, yet nonetheless simply digestible. it's a must-read for future health care pros and somebody who desires to study extra concerning the info at the back of medical practice.

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2). Valproate for Generalized and Unclassifiable Epilepsy 35 • For adequate seizure control: Lamotrigine was found to have almost twice the failure rate of valproate. Topiramate also appeared to have a higher failure rate than valproate, though the result was not statistically significant. • Intention-​to-​treat analysis, per protocol, for 1-​year remission: Valproate is more effective than lamotrigine and topiramate. • For quality adjusted life-​year (QALY) studies, topiramate and lamotrigine have positive incremental costs and negative incremental seizures—​a nd were therefore both inferior to valproate.

2). Valproate for Generalized and Unclassifiable Epilepsy 35 • For adequate seizure control: Lamotrigine was found to have almost twice the failure rate of valproate. Topiramate also appeared to have a higher failure rate than valproate, though the result was not statistically significant. • Intention-​to-​treat analysis, per protocol, for 1-​year remission: Valproate is more effective than lamotrigine and topiramate. • For quality adjusted life-​year (QALY) studies, topiramate and lamotrigine have positive incremental costs and negative incremental seizures—​a nd were therefore both inferior to valproate.

Endpoints: Primary endpoints included both cognitive and functional assessments: (1) Change from baseline on the Severe Impairment Battery (SIB) and (2) change from baseline on the modified 19-​item AD Cooperative Study–​ Activities of Daily Living Inventory (ADCS-​ADL19), both at week 24. Secondary endpoints: (1) Clinician’s Interview-​Based Impression of Change Plus Caregiver Input (CIBIC-​Plus), (2) Neuropsychiatric Inventory (NPI), (3) Behavioral Rating Scale for Geriatric Patients (BGP). 2).

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50 studies every neurologist should know by David Y. Hwang


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